C-H Activation has emerged as an attractive method for the synthesis of C-C and C-X bonds. However, C-H activation/cross-coupling reactions with C(sp3) centres are still underdeveloped compared to C(sp2)-C(sp2) cross-coupling methodologies. Restricted substrate scope, harsh conditions and poor chemoselectivity impedes broad application of C(sp3)-H activation strategies in chemical synthesis. New mechanistic paradigms need to be uncovered to overcome these limitations and further increase the synthetic utility of C(sp3)-H activation. Our group is therefore interested in developing alternative methodologies by applying photocatalytic strategies to traditional directing group assisted activation of C(sp3)-H bonds.
These methodologies include:
Auxiliary‐Directed C(sp3)−H Arylation by Synergistic Photoredox and Palladium Catalysis
Chem. Eur. J. 2017, 23, 14450-14453. doi:10.1002/chem.201704045
Photoexcited Pd(II) Auxiliaries Enable Light-Induced Control in C(sp3)–H Bond Functionalisation